Journal article
ApoB48-lipoproteins are associated with cardiometabolic risk in adolescents with and without polycystic ovary syndrome
DF Vine, LJ Beilin, S Burrows, RC Huang, M Hickey, R Hart, SD Proctor, TA Mori
Journal of the Endocrine Society | ENDOCRINE SOC | Published : 2020
Abstract
Context: Adolescents with polycystic ovary syndrome (PCOS) have increased incidence of cardiometabolic risk factors including dyslipidemia. Atherogenic apolipoprotein (apo) B-lipoprotein remnants are associated with increased cardiovascular disease (CVD) risk. Objective: The aim of this study was to determine the concentrations of fasting plasma apoB-lipoprotein remnants, apoB48 and apoB100, and their association with cardiometabolic risk factors and androgen indices in adolescent girls with and without PCOS. Design, setting and participants: Participants (n = 184) aged 17 years were recruited in the Menstruation in Teenagers Study from the Western Australian Pregnancy Cohort (Raine) Study. ..
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Awarded by Raine Medical Research Foundation
Funding Acknowledgements
Funding for Core Management of the Raine Study was provided by the University of Western Australia (UWA); Telethon Kids Institute; Raine Medical Research Foundation; UWA Faculty of Medicine, Dentistry and Health Sciences; Women's and Infant's Research Foundation; and Curtin University. This work was supported by grants from the National Health and Medical Research Council of Australia (NHMRC) (Program Grant 35351417; Project Grant 403981). Trevor Mori is supported by a Research Fellowship from the NHMRC (Grant 1136046). Martha Hickey is supported by an NHMRC Practitioner Fellowship (APP 1058935). Additional funds supporting this work were from the Heart and Stroke Foundation of Canada and project funding from Alberta Livestock and Meat Agency (ALMA) (Proctor). Donna Vine is supported by the Canadian Institute of Health Research (CIHR), the Women and Children's Health Research Institute (WCHRI), the Alberta Diabetes Institute (ADI) and a University of Alberta McCalla Professorship.